Assuming It Was There, Where Did It Go?

Glioma Development: Where Did It All Go Wrong?

Investigating the family tree of a tumor to identify its cellular origins is a daunting task. Liu et al. (2011) now use an elegant lineage tracing technique (MADM) to visualize glioma from its earliest stages. They show that mutations originally induced in neural stem cells lie dormant and only trigger malignant transformation following differentiation into oligodendrocyte precursor cells.

Colloidal Silver: Where Does It Go When You Drink It? How Long Does It Stay There?

It matters where you go

a r t i c l e i n f o How does outward foreign direct investment (FDI) affect employment growth of the multinational corporations (MNCs) in the home country? Does the impact of outward investment differ by the level of development of the destination country of the FDI? Using a difference-indifference approach, we assess the impact of starting to invest in less-advanced countries compared with i...

Where should the IOL go when it does not go where it should?

hroughout the latter half of the twentieth century, a series of disruptive innovations and hotly debated issues resulted in general consensus for standard cataract surgery and agreement on the ideal anatomic location for intraocular lenses (IOL); namely, within the capsular bag. Sir Harold Ridley envisioned this outcome from the inception of the IOL, stating “...the site for the prosthesis shou...

Reaction rate theory: what it was, where is it today, and where is it going?

A brief history is presented, outlining the development of rate theory during the past century. Starting from Arrhenius [Z. Phys. Chem. 4, 226 (1889)], we follow especially the formulation of transition state theory by Wigner [Z. Phys. Chem. Abt. B 19, 203 (1932)] and Eyring [J. Chem. Phys. 3, 107 (1935)]. Transition state theory (TST) made it possible to obtain quick estimates for reaction rat...